[{"id":"recent","papers":[{"biol_entities":["idi1","hsd11b1","srebp2","acc1","scd1","bcl-2","alt","bax","il-6","tnf-\u03b1"],"rank":886.0,"pub_date":"2026-05-23T00:00:00Z","slug":"Magnesium-isoglycyrrhizinate-alleviates-alcohol-associated-liver-disease-through-targeting-HSD11B1","exp_assays":["cell viability","quantitative pcr","co-ip","apoptosis","mrna expression","staining","binding","rna-seq","western blot","gene expression"],"doi":"10.1101/2025.10.02.679991"},{"biol_entities":["gar405","egfp ubiquitin","ha ubiquitin","sdeabc","gar","rab5","dota","ubiquitin","flag","ha","egfp","rab5a"],"rank":1286.0,"pub_date":"2026-05-11T00:00:00Z","slug":"Canonical-and-phosphoribosyl-ubiquitination-coordinate-to-stabilize-a-proteinaceous-structure-surrounding-the-Legionella-containing-vacuole","exp_assays":["immunoprecipitation","immunoblot","immunofluorescence","imaging","staining","western blot","stained","intensity"],"doi":"10.1101/2025.07.22.666189"},{"biol_entities":["lsa3-c","mlsa3","lsa3","rex3","aldo","aldolase","pk","exp2","proteinase k","gfp"],"rank":1309.0,"pub_date":"2026-05-20T00:00:00Z","slug":"The-vaccine-candidate-Liver-Stage-Antigen-3-is-exported-during-Plasmodium-falciparum-infection-and-required-for-liver-stage-development","exp_assays":["live fluorescence imaging","ifa","immunofluorescence microscopy","localized","immunoblotting","qrt-pcr","stained"],"doi":"10.1101/2025.07.18.665593"},{"biol_entities":["stf","iwr1","iwr","axin","axin1","wnt3a","tnks","tnks1","tnks2","axin2","gspt1","\u03b2-catenin","flag","wnt","mcherry","gfp"],"rank":2419.0,"pub_date":"2026-05-14T00:00:00Z","slug":"Role-of-tankyrase-scaffolding-in-the-\u03b2-catenin-destruction-complex-and-WNT-signaling","exp_assays":["frap","growth","western blot"],"doi":"10.1101/2025.09.22.677768"},{"biol_entities":["peripherin-2","prph2ct","cng\u03b21","cng\u03b11","rom1","prph2","rds","rhodopsin","flag","rho","myc"],"rank":2558.0,"pub_date":"2026-05-28T00:00:00Z","slug":"The-tetraspanin-disc-proteins-peripherin-2-and-ROM1-facilitate-CNG-channel-localization-to-the-rod-outer-segment","exp_assays":["counterstained","immunostained"],"doi":"10.1101/2025.09.30.679618"},{"biol_entities":["il-23 p19","fadd28","eccc1","il-12 p35","esat-6","esx","tbet","cd8a","ifn-\u03b3","ifng","il-17a","il17a","ly6g","cd4","cd3"],"rank":2670.0,"pub_date":"2026-05-10T00:00:00Z","slug":"Mycobacterium-tuberculosis-suppresses-protective-Th17-responses-during-infection-through-multiple-mechanisms","exp_assays":["ics","cfu","flow cytometry"],"doi":"10.1101/2025.05.08.652811"},{"biol_entities":["pcyc1","fli1rrll","comp","ews","fli1","egfp","gfp"],"rank":3053.0,"pub_date":"2026-05-15T00:00:00Z","slug":"Human-Oncogene-EWS-FLI1-Functions-as-a-Pioneer-Factor-in-Saccharomyces-cerevisiae","exp_assays":["chip-seq","facs","gene expression"],"doi":"10.1101/2025.10.22.680884"},{"biol_entities":["cas9","gfp","gapdh","\u03b2-actin","cdk1","actb","\u03b3h2ax","flag","irf3","isg15","xrn1","47s","stat1","rig-i","cyclin a","atr","atri","j2","pre-rrna","isg56","mda5","cdk4","aph","ifnb","47s pre-rrna","mavs","cyclin b","rpp","cdk1i","rnap i"],"rank":3557.0,"pub_date":"2026-05-29T00:00:00Z","slug":"RIG-I-like-receptors-sense-replication-stress-through-ribosomal-DNA-integrity-to-drive-inflammation","exp_assays":["expression","images","western blot","rt-qpcr","rna-seq","whole genome sequencing","immunofluorescence","levels","flow cytometry","immunoblot","pcr","edu","wgs","translocation","pd","rna-fish","ppprna-seq"],"doi":"10.64898/2026.05.27.728122"},{"biol_entities":["ck19","ca19-9neg","ca19-9pos","kcrlslf","fut3","ca19-9","apcaf","pegfr","fbln3","saa3","cc3","ki67","stat3","akt","erk","egfr","cd8","rosa26","cd45","p65","-\u03bab","kc","smad2","nf-kb","tgfb","il1a","efemp1","slpi","cd74","cd8a","pdpn","cd25","tgfb1","ls","foxp3","rls","cofilin","h2-ab1"],"rank":3566.0,"pub_date":"2026-05-26T00:00:00Z","slug":"CA19-9-induces-microenvironment-remodeling-in-pancreatic-ductal-adenocarcinoma","exp_assays":["scrna-seq","gene expression","expression","rna-seq","if","staining","qrt-pcr","elisa","flow cytometry","phosphorylated","immunoblot","qpcr","gsea","scrnaseq","ihc","protein levels","he","ihc staining","histological","tumor volume","histologic","tumor weight","mt"],"doi":"10.64898/2026.05.22.727290"},{"biol_entities":["gfp","mcherry","egfp","gapdh","zo-1","sox2","\u03b2-gal","flag","gal4","\u03b2-catenin","gm130","grh","arf1","golph3","giantin","eb3","ndc80","nuf2","spc25","mis12","msps","dicer2","mcd8","cdk5rap2","eb1","spc105r","dpn","spc105","arf1wt","nnf1a","kmn1","sec71"],"rank":3574.0,"pub_date":"2026-05-24T00:00:00Z","slug":"A-Moonlighting-Function-of-Kinetochore-Complex-Proteins-in-Golgi-Assembly-of-Neural-Stem-Cells","exp_assays":["intensity","localization","stained","wb","kymographs","pla","immunoblot","localized","edu incorporation","immunostaining","edu","blots","localizes","comets","micrograph images"],"doi":"10.64898/2026.05.24.727544"},{"biol_entities":["actin","vinculin","rnase a","tubulin","ivl","sh","halo","s9","halotag","krt16","krt6a","s100a8","krt10","jnk","atr","atm","vp","znf750","a3a","c-jun","vpr","apobec3","apobec3a","ifit1","apobec3c","apobec3g","apobec3f","apobec3b","apobec3h","cra","apobec3d","grhl3","sprr1b","ssdna cytidine deaminase"],"rank":3579.0,"pub_date":"2026-05-26T00:00:00Z","slug":"Squamous-state-excursions-activate-APOBEC3A-in-cancer","exp_assays":["scrna-seq","facs","expression","rna-seq","staining","mrna expression","flow cytometry","immunoblot","qpcr","immunoblotting","growth curves","gsea","pcr","quantitative rt-pcr","rna sequencing","clonogenic survival"],"doi":"10.64898/2026.05.24.727500"},{"biol_entities":["gapdh","h3k4me3","nanog","oct4","sox2","crispri","\u03b1-tubulin","smo","gli2","histone h3","h3k36me3","e-cadherin","ash2l","brachyury","tss","sox1","tubb3","notch1","hes1","olig2","lif","\u03b1tubulin","tss1","tss2","ash2l tss1"],"rank":3587.0,"pub_date":"2026-05-27T00:00:00Z","slug":"Co-option-of-a-mouse-specific-retrotransposon-rewires-Ash2l-isoform-usage-to-prime-developmental-promoters","exp_assays":["facs","expression","images","western blot","chip-seq","rt-qpcr","rna-seq","staining","rt-pcr","flow cytometry","qpcr","blot","methylation","protein levels","chip","immunoprecipitation","ip","trimethylation","tt-tss-seq","tss-seq","cage","ttchem-seq","gastruloid assays"],"doi":"10.64898/2026.02.25.707914"},{"biol_entities":["gfp","ki67","gapdh","vinculin","tdtomato","tgf-\u03b2","myh11","acta2","pdk4","smad2","glut1","\u03b1sma","cd68","apoe","pfkfb3","tgf\u03b2","acly","alk5","acss2","sm22","pdh293","pdk4ismcko"],"rank":3607.0,"pub_date":"2026-05-21T00:00:00Z","slug":"Metabolic-control-of-smooth-muscle-cell-phenotype-switching-in-atherosclerosis","exp_assays":["intensity","expression","images","western blot","atac-seq","rna-seq","staining","phosphorylation","phosphorylated","qpcr","ocr","ecar","immunostaining","western blotting","lc","immunoprecipitation","ms","liquid chromatography","acetylated","oxygen consumption","spare respiratory capacity"],"doi":"10.64898/2026.05.19.726223"},{"biol_entities":["fasnwtegfrc1025a","fasnkoegfrwt","fasnwt egfrc1025a","fasnko egfrwt","fasnko","fasnwt","fasnwtegfrwt","fasnko b2mkd","egfrwt egfrc1122a","egfrwt","mhc-","acly","fasn","ifn\u03b3","mhc","b2m","mtor","mhc-i","pd-1","pi3k","egfr","ova","gfp"],"rank":3615.0,"pub_date":"2026-05-26T00:00:00Z","slug":"Lipogenesis-driven-EGFR-palmitoylation-enables-metastatic-immune-evasion-in-triple-negative-breast-cancer","exp_assays":["lipidomic analysis","lipidomic profiling","palmitoylation","protein expressions","histology","lc-ms","bioluminescence imaging","bli","ms","lc","gsea","flow cytometry","mrna expression","gene set enrichment analysis","survival","western blot","expression"],"doi":"10.64898/2026.05.21.726063"},{"biol_entities":["gfp","gapdh","paxillin","rhoa","\u03b1-tubulin","flag","rfp","rac1","fas","mscarlet","mng","\u03b2-catenin","mlc","kank1","arp2/3","lifeact","rock1","rock2","eb3","rock","kank2","kank","ccdc66","daam2"],"rank":3617.0,"pub_date":"2026-05-20T00:00:00Z","slug":"CCDC66-couples-actin-microtubule-crosslinking-to-KANK1-associated-microtubule-targeting-and-focal-adhesion-turnover","exp_assays":["expression","localization","stained","survival","immunofluorescence","immunoblotting","dap","confocal images","co-stained","pulldown","co-immunoprecipitation","dapi","counterstained","wound closure","wound healing assay","phase-contrast images","kaplan-meier","live-cell imaging","phalloidin","phal","co-precipitated","wound","wound-healing assays","phase-contrast","migrating","idin"],"doi":"10.64898/2026.05.19.723697"},{"biol_entities":["tgf\u00df","p1np","opg","pth1r","f3","ebf3","ter119","perilipin","pth","bg","creert2","trap","ctx","sox9","sp7","bglap","cd45","cd31","cxcl12","car","endomucin","tdtomato","rosa26","gfp"],"rank":3618.0,"pub_date":"2026-05-26T00:00:00Z","slug":"Intermittent-parathyroid-hormone-employs-autonomous-and-non-autonomous-mechanisms-to-drive-osteogenesis-from-Ebf3-expressing-skeletal-progenitor-cells","exp_assays":["fluorescent image","microct images","fluorescent images","rna-sequencing","confocal images","morphology","immunohistochemical staining","phospho","flow cytometry","mrna expression","rt-qpcr","expressed","expression","facs","gene expression"],"doi":"10.64898/2026.05.21.726951"},{"biol_entities":["cas9","gfp","egfr","cd19","her2","crispr","car","cd45","luciferase","myc","flag","cd69","a2","trac","ifng","notch1","tcr","cars","hla-a2","notch2","ngfr","darpin","adam","her2car","snipr","mantis-12","sniprs","ram7","45ecd","gamma secretase"],"rank":3629.0,"pub_date":"2026-05-24T00:00:00Z","slug":"Spatial-Regulation-of-CAR-Signaling-Enables-Logic-Gated-Activity","exp_assays":["expression","stained","survival","staining","growth","viability","flow cytometry","weight","h&e staining","bioluminescence imaging","viable","flow staining","cell killing","steadyglo luminescence assay"],"doi":"10.64898/2026.05.22.726983"},{"biol_entities":["s","rpn1fl","rpn102","sftpccreert2","na\u207a/k\u207a-atpase","amfr","p24","s protein","n protein","npl4","rpn1","luc","ace2","vcp","gag","ubiquitin","flag","\u03b1-tubulin","his","luciferase","gapdh","egfp"],"rank":3665.0,"pub_date":"2026-05-21T00:00:00Z","slug":"Ribophorin-1-Governs-Spike-Abundance-of-Highly-Pathogenic-Coronaviruses-by-ER-associated-degradation","exp_assays":["n-glycosylation","co-precipitated","nanofcm","luciferase activity","ubiquitination","dapi","immunoprecipitation","immunoblotting","immunoblot","immunofluorescence staining","fitc","cryo-em","qrt-pcr","immunofluorescence","staining"],"doi":"10.64898/2026.05.20.726704"},{"biol_entities":["nua-3 toc1","nua","nua f1r2","nua-4","nua-3","rpn1a","rpt5b","nup136pro","nup136","prr9","toc1pro","prr7","prr5","toc1","ubq","adk","cca1","r2","luc","yfp","myc","cfp","h3","tap","ha","gfp"],"rank":3667.0,"pub_date":"2026-05-23T00:00:00Z","slug":"Nuclear-basket-localized-proteasomes-maintain-circadian-period-through-nuclear-TOC1-proteolysis","exp_assays":["bioluminescence rhythms","immunoblotted","length","co-ip","co-immunoprecipitation","immunoprecipitated","protein levels","confocal microscopy","immunoblotting","immunoblot","immunoblots","interaction","expression"],"doi":"10.64898/2026.05.21.727017"},{"biol_entities":["fad1","vctf1","ps1 fad","ctf1","endoglin","col iv","ephb2","rab7","rab5","vegf-a","lamp2","vegfr2","ps1","zg","fad","flag","myc","\u03b2-actin","erk1","vinculin","gapdh"],"rank":3668.0,"pub_date":"2026-05-20T00:00:00Z","slug":"PS-FAD-mutants-and-\u03b3-secretase-inhibition-accumulate-VEGFR2-derived-peptide-VCTF1-suppressing-brain-VEGFR2-dimerization-angiogenesis-and-neuroprotection","exp_assays":["oti12c1","wbs","iped","co-iped","co-localized","photomicrographs","co-immunostained","co-localization","immunostained","migration","co-stained","confocal images","phosphorylated","wb","stained","images"],"doi":"10.64898/2026.05.12.724648"},{"biol_entities":["adar1p90","bri3bp","adar1\u03b4i13","gfpp110","p90","hnrnpa1","mda5","pkr","adar1p110","p110","lamin b1","adar1","flag","\u03b1-tubulin","\u03b2-actin","eif2\u03b1","gapdh"],"rank":3700.0,"pub_date":"2026-05-29T00:00:00Z","slug":"Intron-13-retention-expands-the-ADAR1-isoform-repertoire-to-rewire-PKR-signaling-and-promote-tumorigenesis","exp_assays":["eclip-seq binding","eclip-seq","xenograft","rip","immunoprecipitates","ip","blot","qpcr","rt-pcr","wb","binding","rna-seq","rt-qpcr","western blot","expression"],"doi":"10.64898/2026.05.26.727889"},{"biol_entities":["mkk5","spy-23","sec-2","sec-5","spy-4","mkk4","pep1","tbid","ppase","aal","spy","sumo","mapk","fls2","flg22","gst","fos","his","sec","gfp"],"rank":3704.0,"pub_date":"2026-05-10T00:00:00Z","slug":"Linking-sugar-sensing-to-immunity-in-plants-via-O-glycosylation","exp_assays":["o-fucosylated","length phenotype","bio-layer interferometry","cbb","immunoblotted","length","bli","coomassie brilliant blue","blots","ip","immunoprecipitated","blot","immunoblot","immunoblots","phosphorylation","binding","pull-down","stained","expression"],"doi":"10.64898/2026.05.04.722566"},{"biol_entities":["aclyf","acss2f","atp5f1a","h4c1","acss2","acss1","acly","trp53","cdx2","creert2","luc","rfp","il-6","p16","tnf-\u03b1","luciferase","h4","gfp"],"rank":3706.0,"pub_date":"2026-05-19T00:00:00Z","slug":"Gut-Microbiota-derived-Acetate-Safeguards-the-Colonic-Epithelial-Acetyl-CoA-Reserve-to-Avert-Colonic-Senescence","exp_assays":["acetyl-","acetyl-proteomics","confocal microscopic images","survival curves","immunoprecipitation","acetylation","h&e staining","body weight","h&e stained","immunofluorescence staining","mass spectrometric","staining","rna-seq","rt-qpcr","survival","western blot","expression","facs"],"doi":"10.64898/2026.05.15.725523"},{"biol_entities":["tdtomato\u207agfp\u207a","cx3cl1\u207a","ter119\u207bcd45\u207bcd31\u207b","pdgfr\u03b1\u207b","tdtomato\u207b","pdgfr\u03b1\u207a","cx3cr1\u207a","cx3cr1 gfp","tdtomato\u207a","cx3cl1","cd31\u207a","cx3cr1","ubc","creert2","trap","cdh5","pdgfra","cd45","cd31","col1a1","tdtomato","cre","gapdh","gfp"],"rank":3742.0,"pub_date":"2026-05-27T00:00:00Z","slug":"Muscle-to-Bone-CX3CL1-Signaling-Promotes-Skeletal-Repair-Through-CX3CR1-Osteoprogenitors","exp_assays":["histomorphometry","histomorphometric","ded","ftir","bmd","toluidine blue","rnascope in situ hybridization","\u03bcct","dapi","flow cytometric","h&e stained","qpcr","flow cytometry","immunofluorescence","mrna expression","stained"],"doi":"10.64898/2026.05.24.727531"},{"biol_entities":["von willebrand factor","cluster of differentiation 34","collagen type iv alpha 1 chain","collagen type iv alpha 2 chain","asah1fl","family pyrin domain containing 3","vesicle-associated protein","vessel endothelial hyaluronan receptor 1","insert domain receptor","interleukin-18","matrix metallopeptidase 9","vascular cell adhesion molecule 1","intercellular adhesion molecule 1","matrix metallopeptidase 2","plvap","c-c motif chemokine ligand 2","albcre","col4a2","endothelial nitric oxide synthase","asah1","tlr9","gasdermin d","interleukin-6","endothelin-1","nos3","nitric oxide synthase 3","gamma","col4a1","gsdmd","rage","ccl2","vcam1","cd45","tnf-\u03b1","hmgb1","ib4","tgf-\u03b2","cd11b","enos","cxcr4","vwf","tumor necrosis factor alpha","alt","ast","ppia","hprt1","klf2","kdr","casp1","il18","tlr4","tnf","mmp2","mmp9","collagen i","cd34","edn1","icam1","thbd","icam-1","isolectin b4","tumor necrosis factor","nlrp3","vcam-1","et-1","lyve1","caspase-1"],"rank":3761.0,"pub_date":"2026-05-27T00:00:00Z","slug":"An-LSEC-focused-computational-drug-repurposing-platform-for-liver-fibrosis-Identification-of-vorinostat-and-other-LSEC-protective-candidates","exp_assays":["scrna-seq","expression","rna-seq","binding","elisa","interaction","immunofluorescence staining","qpcr","body weight","dapi","echocardiography","tunel","ultrasonography"],"doi":"10.64898/2026.05.23.727430"},{"biol_entities":["p21","ha","his","flag","gst","rb","parp1","p53","che","mortalin","parp1kd","alars","alars1","alarskd","mortalinkd","alarsoe"],"rank":3764.0,"pub_date":"2026-05-18T00:00:00Z","slug":"AlaRS-mediated-lactylation-shields-PARP1-from-ubiquitination-to-promote-HNSCC-progression","exp_assays":["expression","stained","western blot","survival","rna-seq","binding","staining","mass spectrometry","qrt-pcr","cell proliferation","protein levels","crystal violet","ihc staining","edu","binding affinity","co-ip","ip","ubiquitination","ms","bli","cell viability","xenograft","cck-8","cck-8 assay","colony formation assay","tsa","dose-dependent","lactylation","lactylated"],"doi":"10.64898/2026.05.18.725782"},{"biol_entities":["\u03b1-lysozyme","\u03b2ctn","\u03b2ctn4a","\u03b2-catenin \u03b2ctn","mclass","wnt3a","bctc","pam","axin2","\u03b2-catenin","tc","halo","tub","tubulin","wnt","lysozyme","mcherry"],"rank":3771.0,"pub_date":"2026-05-15T00:00:00Z","slug":"Oncomimetic-\u03b2-catenin-activity-onset-duration-and-region-defines-aberrant-intestinal-development","exp_assays":["msios","clsm immunofluorescence","msio","morphometric","mip","cl","msi","micrographs","fluorescence intensity","protein levels","growth","western blot","fluorescence","expression","intensity"],"doi":"10.64898/2026.05.07.723518"},{"biol_entities":["ck2","insp","ip6k1","sfb","brca2","i-scei","idr1","gst","plk1","flag","ccnb1","\u03b3h2ax","myc","rad51","cdk1","gapdh","gfp"],"rank":3784.0,"pub_date":"2026-05-13T00:00:00Z","slug":"The-inositol-pyrophosphate-5-InsP7-promotes-DNA-repair-by-disrupting-RAD51-binding-to-the-C-terminus-of-BRCA2","exp_assays":["sax-hplc","autoradiography","immunofluorescence images","dna damage","dna","immunoblots","phosphorylated","interaction","phosphorylation","immunofluorescence","staining","pull-down","stained"],"doi":"10.64898/2026.05.10.723974"},{"biol_entities":["fbp1","oron","nus1","nogo-b","adiporon","adipor1","adipor2","ngbr","amylase","rtn4","gck","h3k14ac","insr","on","alp","lipase","histone h3","pp2a","h3k18ac","kat7","db","ppargc1a","pcx","hba1c","pck1","g6pc","ampk","alt","ast","adiponectin","leptin","c-peptide","albumin","foxo1","glucagon"],"rank":3791.0,"pub_date":"2026-05-22T00:00:00Z","slug":"NgBR-controls-hepatic-adiponectin-signaling-competence-through-KAT7-dependent-chromatin-regulation","exp_assays":["expression","survival","rna-seq","phosphorylation","immunoblot","qpcr","immunohistochemistry","body weight","chromatin immunoprecipitation","chip","protein","bone","quantitative pcr","body","food intake","gtt","itt","locomotor activity","energy expenditure","histone acetylation","cell viability assay","respiratory exchange ratio","lean","fat","rer","lipid","bone mineral density","insulin","clams","dexa","dual-energy x-ray absorptiometry"],"doi":"10.64898/2026.05.20.726643"},{"biol_entities":["disc1","hoxa2","hoxb4","tph2","cspg4","nkx2-2","lmx1b","nkx6-1","nr2f2","fgf4","gata2","gata3","foxa2","map2","gfap","5-ht","shh","hsc","tdtomato","mcherry"],"rank":3793.0,"pub_date":"2026-05-29T00:00:00Z","slug":"Human-hindbrain-organoids-with-segment-specific-5-HT-neurons-for-motor-modulation","exp_assays":["mea","bright-field images","rate","fluorescence intensity","immunostaining","qpcr","imaging","rna-seq","expressed","expression","gene expression","scrna-seq"],"doi":"10.64898/2026.05.27.726154"},{"biol_entities":["ikk-\u03b2","msk1","mapkapk2","ifn-\u03b1","pink1","mic60","optn","ifn-\u03b3","p38","tnfa","parkin","tax1bp1","yfp","ubiquitin","p62","actb","tnf-\u03b1","stat3"],"rank":3800.0,"pub_date":"2026-05-13T00:00:00Z","slug":"PINK1-Parkin-dependent-mitophagy-mediates-astrocytic-inflammatory-responses-to-mitochondrial-damage","exp_assays":["rna-sequencing","blots","rna sequencing","western blots","immunostaining","gsea","qpcr","phospho","phosphorylated","staining","expressed","expression","gene expression"],"doi":"10.64898/2026.05.11.724378"},{"biol_entities":["h2ax\u207a","ipmkf","h2ax\u207b","ipmkiec","cdk5rap3","epcam\u207a","fbxo22","cullin1","ipmk","skp1","tgf\u03b2","ire1","chop","h4k16ac","smad2","il-1\u03b2","myc","h3","hdac3","h3k27ac","smrt"],"rank":3809.0,"pub_date":"2026-05-27T00:00:00Z","slug":"Fasting-disrupts-the-InsP-HDAC3-axis-to-drive-ER-stress-mediated-clearance-of-DNA-damaged-cells-and-enforce-tissue-quality-control","exp_assays":["bright-field","acetylated","activity assay","immunoprecipitation","co-immunoprecipitation","densitometric","activity","acetylation","immunohistochemistry","immunoblotting","immunoblot","densitometry","mass spectrometry","western blot"],"doi":"10.64898/2026.05.24.727426"},{"biol_entities":["pho1;h2","pho1;","exp8","xtr7","pifq","saur22","iaa19","rbcs1a","yuc8","pif4","cab1","toc1","spx","tub2","pho1","chi","gst","myc","his","actin","chs"],"rank":3812.0,"pub_date":"2026-05-13T00:00:00Z","slug":"Non-canonical-role-of-a-PHOSPHATE1-HOMOLOG-2-in-suppressing-seedling-photomorphogenesis-via-the-TOC1-PIF4-module","exp_assays":["yeast two-hybrid interaction","length","pull-down assay","protein levels","immunoblotting","interaction","protein-protein interactions","rt-qpcr","images","expression","gene expression"],"doi":"10.64898/2026.05.09.724007"},{"biol_entities":["clstn1","trim8","ndf","coilin","ppm1g","snap","npm1","halotag","med1","ctcf","halo","hist1","rpb1","sox2","h3k4me3"],"rank":3814.0,"pub_date":"2026-05-25T00:00:00Z","slug":"Large-RNA-polymerase-II-condensates-are-promoter-centric-assemblies-associated-with-early-stages-of-transcription-at-all-expressed-genes","exp_assays":["gro-seq77","tt-seq107","dna-fish","tt-seq","using","gro-seq","fish","colocalization","ip","chip","pulldown","immunoblot","immunofluorescence","chip-seq"],"doi":"10.64898/2026.05.25.727590"},{"biol_entities":["dlx6os1","sp9\u03b4zf","gsp9","sp9\u03b4c","tshz1","glacz","dlx2","rbbp7","dlx6","dlx5","dlx1","sp9","dlx","six3","fign","mbd3","rbbp4","hdac2","chd4","hdac1","arx","zeb2","sox6","flag","v5"],"rank":3818.0,"pub_date":"2026-05-27T00:00:00Z","slug":"Stoichiometric-transcription-factor-partnerships-specify-GABAergic-neuron-subtype-identity","exp_assays":["trackerseq","luciferase reporter activity","coip","cut","ms","co-immunoprecipitation","mass spectrometry","binding","chip-seq","expression","gene expression","scrna-seq"],"doi":"10.64898/2026.05.25.727662"},{"biol_entities":["sar1bh79g","atg2a","atg2","wipi2","rab1","rab1a","morange2","mgfp","snap","arfgap1","lc3b","apex2","p62","gapdh","gfp"],"rank":3822.0,"pub_date":"2026-05-19T00:00:00Z","slug":"ATG2A-engages-RAB1A-and-ARFGAP1-positive-membranes-during-autophagosome-biogenesis","exp_assays":["clem-fibsem","in gel fluorescence image","coip","sem","live cell imaging","proximity labeling","confocal","confocal images","immunoblot","immunoblots","confocal image","immunofluorescence","imaging"],"doi":"10.1101/2025.03.24.645038"},{"biol_entities":["pcna","gfp","ki67","erk","gapdh","pdgfr\u03b1","ng2","gfap","mbp","\u03b2-tubulin","s6","estrogen receptor","olig2","myelin basic protein","plp1","olig1","mag","ube3a","o4","gper","tubb1","cnpase","myelin associated glycoprotein","esr-\u03b1","esr-\u03b2","esr\u03b2"],"rank":3825.0,"pub_date":"2026-05-21T00:00:00Z","slug":"Targeting-UBE3A-and-downstream-estrogen-receptor-\u03b2-signaling-to-restore-oligodendroglial-homeostasis-in-Angelman-syndrome","exp_assays":["expression","stained","proliferation","staining","immunofluorescent staining","imaging","immunofluorescence","phosphorylated","stain","immunofluorescence staining","immunoblot","qpcr","immunoblotting","cell proliferation","morphology","protein levels","edu","dapi","rotarod","ometric","proliferating","cell densities"],"doi":"10.64898/2026.05.21.726878"},{"biol_entities":["be3","vtcn1","irx3","sprr2a","bmp4","tead","taz","ert2","isl1","elf3","gata3","tdt","gata6","p300","ha","actin","h3k27ac"],"rank":3847.0,"pub_date":"2026-05-26T00:00:00Z","slug":"Chromatin-priming-by-transcription-factor-ELF3-awakens-latent-competence-for-human-amniotic-differentiation","exp_assays":["atac","immunostaining","gsea","qpcr","chip-seq","atac-seq","western blot","expression","gene expression","scrna-seq"],"doi":"10.1101/2025.08.04.668400"},{"biol_entities":["zcwpw1","zcwpw2cw","zcwpw2","zcwpw2pwwp","mei4","rec114","rnf212","patm","msh4","gcna","hormad1","iho1","prdm9","rpa2","dmc1","mlh1","sycp1","sycp3","flag","h3k36me3","histone h3","\u03b3h2ax","sox9","h3k4me3","rad51","\u03b2-actin","cas9"],"rank":3848.0,"pub_date":"2026-05-26T00:00:00Z","slug":"Dual-histone-methylation-reader-ZCWPW2-links-histone-methylation-to-initiation-of-meiotic-recombination","exp_assays":["enq-seq","hematoxylin","dapi","immunostained","co-ip","western blotting","immunostaining","end-seq","chip-seq"],"doi":"10.64898/2026.05.22.727067"},{"biol_entities":["crth2","il13ra2","dcx","sdc1","il17ra","gasdermin d","tmem219","rage","cd44","olig2","lc3b","chi3l1","vcl","gpx4","lgals3","caspase-3","parp1","gfap","p62","lamp1","actb","pax6","\u03b2-actin","vinculin","gapdh","pcna"],"rank":3852.0,"pub_date":"2026-05-12T00:00:00Z","slug":"Stage-specific-CHI3L1-YKL-40-signaling-controls-generation-of-oligodendrocyte-precursor-cells-through-IL13R\u03b12-mediated-ferroptosis","exp_assays":["blots","immunoblotting","qpcr","immunofluorescence staining","immunoblots","levels","immunofluorescence","rna-seq","proliferation","expression"],"doi":"10.64898/2026.05.08.723841"},{"biol_entities":["ifi30","cd84","cd1c","ifi44l","hivep1","gzmk","dusp1","cxcl8","cxcr5","nr4a2","oas3","foxp3","nfkbia","fosb","cd1","tnfsf10","ccl3","ccr7","interferon gamma","cd14","s100a9","ifit3","tnf","tnfaip3","stat1","ifitm3","irf9","jun","cd69"],"rank":3881.0,"pub_date":"2026-05-23T00:00:00Z","slug":"Decoding-Immune-Reconstitution-Failure-in-People-Living-with-HIV-through-Single-cell-Genomics","exp_assays":["cis-eqtl","scprism","proportion","cell proportions","cell proportion","scatac-seq","atac","interaction","expressed","expression","gene expression","scrna-seq"],"doi":"10.64898/2026.05.21.726797"},{"biol_entities":["rec8\u03b4","gim1\u03b4","spo11\u03b4 spo13\u03b4 gim3\u03b4","gim4\u03b4","gim3\u03b4","gim2\u03b4","tub2\u03b4","gim3\u03b4 tub2","gim5\u03b4","spo11\u03b4 spo13\u03b4","gim6\u03b4","spc42","nup170","gim3","sgo1","hxk2","tub1\u03b4","sorf2","zym","tub2","tub1","htb1","gal4","hsp104","act1","er","gal","mcherry","gfp"],"rank":3890.0,"pub_date":"2026-05-20T00:00:00Z","slug":"Prefoldin-function-links-meiotic-chromosome-segregation-with-cellular-remodeling-and-reveals-tubulin-sensitivity-of-the-meiotic-spindle","exp_assays":["co-segregation","sequestration","mis-segregation","colony growth","live-cell imaging","meiosis","dapi","ip","protein levels","viability","imaging","mass spectrometry","staining","western blot","imaged","images"],"doi":"10.64898/2026.05.20.726416"},{"biol_entities":["mc\u03b4itgb1","mcwt","tomato lectin","ship1","\u03b2-hexosaminidase","p2x7","st2","itgb1","fc\u03b5ri","icam-1","ige","il-33","wt","cd11b","cd45","cd31","c-kit","tdtomato","bsa","pi3k","akt"],"rank":3905.0,"pub_date":"2026-05-11T00:00:00Z","slug":"Anchored-for-action-a-dual-role-for-integrin-\u03b21-in-mast-cell-perivascular-positioning-and-vasoactivity-to-license-leukocyte-recruitment","exp_assays":["dylight 488","2pm","2-photon microscopy","fura-2","confocal laser scanning microscopy","af647","flow cytometry","image","expression","intensity"],"doi":"10.64898/2026.05.07.723399"},{"biol_entities":["gfp","cd3","cd19","cd8","cd4","lck","rosa26","cre","cd45","actb","cd11b","tnf","ifn-\u03b3","cd8\u03b1","cd25","rag2","cd44","cd28","ert2","il-7","foxp3","cd90.2","tcr\u03b3\u03b4","nk1.1","glycoatp","mitoatp","cd3\u03b5","nr5a2","cd8\u03b2","lrh-1","cd9.2"],"rank":3906.0,"pub_date":"2026-05-14T00:00:00Z","slug":"Nuclear-receptor-LRH-1-regulates-early-T-cell-development-in-mice","exp_assays":["gene expression","expression","rt-qpcr","h&e-stained","flow cytometry","body weight","cell death","cell count","rate assay"],"doi":"10.64898/2026.05.11.724315"},{"biol_entities":["prom2ap","haloligand","m2ap","ron2","mlc1","sec13","rop1","imc1","imc3","mic2","rab6","tgif","emgfp","ty","jf646","halo","tubulin","mcherry","gfp"],"rank":3913.0,"pub_date":"2026-05-24T00:00:00Z","slug":"TGIF-is-a-Golgin-like-protein-required-for-Golgi-structural-maintenance-and-function-in-Toxoplasma-gondii","exp_assays":["pulse-chase recycling assay","pulse-chase trafficking assay","morphologies","blots","colocalization","morphology","immunofluorescence","staining","western blot","stained","localization","images","intensity"],"doi":"10.64898/2026.05.21.726867"},{"biol_entities":["vexa","uba1m41l","uba1m41v","uba1wt","vexas","ube2g2","ve","uba1","gm130","sting","cd14","stat1","tnf\u03b1","ube2j1","cgas","ubiquitin","il-6"],"rank":3914.0,"pub_date":"2026-05-29T00:00:00Z","slug":"Cell-autonomous-inflammation-in-VEXAS-is-mediated-by-cGAS-STING","exp_assays":["bf","brightfield","morphology","localized","transmission electron microscopy","tem","immunoblotting","qpcr","immunoblot","elisa","immunofluorescence"],"doi":"10.64898/2026.05.26.727520"},{"biol_entities":["casrx","kras4b","k-ras","casp8","nf1","ras","p1","casp3","bcl2","kras","pkc\u03b4","flag","ki-67","ha","gfp"],"rank":3919.0,"pub_date":"2026-05-21T00:00:00Z","slug":"Selective-Pyroptosis-in-NF1-Deficient-Cells-through-PKC\u03b4-Agonism","exp_assays":["soft-agar assays","hoechst-33342","pull-down assays","immunoprecipitations","cell viability","immunostaining","dose-response curves","immunoblotting","qpcr","viability","pull-down"],"doi":"10.64898/2026.05.19.726276"},{"biol_entities":["notch1kd","tim3","granzyme b","cd44","notch1","ifn\u03b3","lag3","pd1","cd24","sox2","oct4","nanog","cd8"],"rank":3932.0,"pub_date":"2026-05-26T00:00:00Z","slug":"Breast-cancer-stem-cells-mediated-CD8-T-cell-exhaustion-among-different-molecular-subtypes-of-breast-cancer-regulated-via-NOTCH1-RBPJ-PD-L1-axis","exp_assays":["cytofluoromicrographs","tumorsphere assay","tumors","flow-cytometric","-localization","confocal microscopic","western blotting","ihc","protein expression","rt-pcr","expression","gene expression"],"doi":"10.64898/2026.05.22.727059"},{"biol_entities":["makr4","makr6","pin1hl","tmk1","canar","camel","pin1","mch","mtq2","mng","fls2","gus","flag","gfp"],"rank":3935.0,"pub_date":"2026-05-30T00:00:00Z","slug":"MAKR6-targets-TMK-and-CAMEL-CANAR-receptor-complexes-for-auxin-canalization-in-Arabidopsis","exp_assays":["flim","density","fret","immunoprecipitation","co-ip","interaction","qrt-pcr","staining","images","expression"],"doi":"10.1101/2025.10.07.680881"},{"biol_entities":["fegfp","vsvegfp","sjn","somi","hprase","v-a","nucleocapsid protein","a4","n protein","eg","v-","ace2","hace2","egfp"],"rank":3937.0,"pub_date":"2026-05-14T00:00:00Z","slug":"Nanoscopy-Reveals-Heparan-Sulfate-Clusters-as-Docking-Sites-for-SARS-CoV-2-Attachment-and-Entry","exp_assays":["immunolabeled","bright field","immunolabelled","sted","colocalized","sted images","confocal","confocal images","confocal image","fluorescence","intensity"],"doi":"10.1101/2025.09.08.674976"},{"biol_entities":["anks1bf","foxo6","anks1b","d1","drd1","d2","foxo1","foxo3","cre","egfp","mcherry","cbp","h3k27ac"],"rank":3941.0,"pub_date":"2026-05-24T00:00:00Z","slug":"ANKS1B-in-the-Nucleus-Accumbens-controls-escalated-cocaine-self-administration-via-regulating-CBP-FoxO3-complex","exp_assays":["-administration","behavioral testing","rna-sequencing","western blots","chip","protein levels","blot","qpcr","interaction","expressed","western blot","expression"],"doi":"10.64898/2026.01.11.698845"},{"biol_entities":["ube3a","p2ry12","ptx3","syn1","syt1","trem2","iba1","cd68","adam10","tnfa","il6","il1b","mmp9","c3","tnf","tnf\u03b1","il-1\u03b2","tnf-\u03b1","gapdh"],"rank":3943.0,"pub_date":"2026-05-28T00:00:00Z","slug":"Neuronal-UBE3A-loss-engages-a-TNF-driven-neuron-to-microglia-axis-that-promotes-synapse-remodeling","exp_assays":["blots","densitometric","confocal images","qpcr","immunofluorescence","staining","rna-seq","stained","images","expression"],"doi":"10.64898/2026.05.27.728269"},{"biol_entities":["fcgr4","lyzm","fc\u03b3r3","fcgr3","siglec f","ppar\u03b3","wtap","hk2","eea1","wt","ly6g","eyfp","cd11b","pparg","cre"],"rank":3943.0,"pub_date":"2026-05-27T00:00:00Z","slug":"WTAP-mediated-epitranscriptomic-program-in-alveolar-macrophages-confers-prolonged-protection-against-postinfluenza-bacterial-pneumonia","exp_assays":["chemotaxis assay","histology","ms/ms","lc","flow cytometric","tem","immunoblotting","immunofluorescence staining","flow cytometry","qrt-pcr","mrna expression","imaging","rna-seq","expression"],"doi":"10.64898/2026.05.23.727154"},{"biol_entities":["daf-36","daf-9","dhs-26","dhs-16","dhrs1","mir-84p","daf-12","ttx-3","raga-1","fxr","scarlet","luc","rfp","flag","mtor","\u03b2-actin","gfp"],"rank":3948.0,"pub_date":"2026-05-15T00:00:00Z","slug":"mTOR-regulates-longevity-through-a-bile-acid-like-hormonal-mechanism-and-DHS-26-DHRS1","exp_assays":["life","differential interference contrast","dic","fluorescence intensity","rna sequencing","morphology","immunoblots","fluorescence images","fluorescence","expression"],"doi":"10.64898/2026.05.13.724957"},{"biol_entities":["ixist","chrxcast","halo hnrnpu","h3ser10p","mcph1","chrx129","setbd1","ist","raser","xi","hnrnpu","ciz1","setdb1","xist","tbp","h2ak119ub1","halo","mettl3","h3k27me3","h3k4me3","fkbp12f36v"],"rank":3949.0,"pub_date":"2026-05-21T00:00:00Z","slug":"A-key-role-for-chromosome-compartment-interactions-in-directing-Xist-RNA-localisation","exp_assays":["rap-seq","immuno-fish","chrrna-seq","rna fish","counter","counterstained","fish","rna","hi-c","3d-sim","staining","if","western blot","expression"],"doi":"10.64898/2026.05.19.726226"},{"biol_entities":["hjak1","ifn-\u03b1","ifit1","strepii","oas1","trex1","ifn-\u03b3","il6","ifn-\u03b2","stat1","isg15","cxcl10","flag","il-6","ha","jak1"],"rank":3949.0,"pub_date":"2026-05-12T00:00:00Z","slug":"The-gut-microbiota-metabolite-Urolithin-A-mitigates-JAK-signaling-to-suppress-cytokine-mediated-autoimmune-diseases","exp_assays":["in vitro kinase assay","cck-8","cell viability","immunoprecipitation","densitometric","qpcr","immunoblot","interaction","phosphorylation","elisa","pull-down"],"doi":"10.64898/2026.05.08.723914"},{"biol_entities":["lipt2","klip","gcsh","lipt1","slc31a1","ndi1","fdx1","slc25a3","mitolbnox","2-oxoglutarate dehydrogenase","4e-bp1","lias","dlat","aox","dlst","dbt","pdh","ldha","pyruvate dehydrogenase","lbnox","ulk1","pc","ampk","p70s6k","ogdh","pyruvate carboxylase","\u03b2-actin"],"rank":3960.0,"pub_date":"2026-05-22T00:00:00Z","slug":"Mitochondrial-copper-stabilizes-lipoylated-TCA-cycle-proteins-to-sustain-metabolism-and-proliferation","exp_assays":["in-gel fluorescence imaging","gc-ms","activity assay","coomassie staining","ms","trypan blue","immunoblot","viability"],"doi":"10.64898/2026.05.20.726656"},{"biol_entities":["brca2aid","brca2wt","gclmwt","gclmhypo","palb2aid","brca1aid","ggt1","xrcc1","palb2","gclm","maid","lhx2","ostir1","fen1","brca2","tp53","nrf2","parp1","aid","brca1","rad51","tubulin","annexin v"],"rank":3971.0,"pub_date":"2026-05-17T00:00:00Z","slug":"BRCA2-loss-triggers-a-downward-spiral-of-genomic-instability-via-ROS-dependent-metabolic-collapse","exp_assays":["fucci","alkaline comet assay","colony formation assay","ocr","oxygen consumption rate","pcr","body weight","dot blot","gsea","immunoblot","flow cytometry","growth","rna-seq","survival","western blot","expression","facs"],"doi":"10.64898/2026.05.15.725601"},{"biol_entities":["slc25a35","slc25a34","rps6ser240","ppar\u03b4","laminin","rps6","pgc-1\u03b1","pep","\u03b1-actinin","mbp","atp5a","mtor","gapdh"],"rank":3979.0,"pub_date":"2026-05-29T00:00:00Z","slug":"Mitochondrial-control-of-amino-acid-catabolism-by-a-fasting-inducible-mitochondrial-carrier","exp_assays":["sunset assay","muscle","transport assay","competition","uptake assay","electron microscopy","metabolomics","ponceau s staining","immunoblotting","qpcr","immunoblot","immunofluorescence","rna-seq"],"doi":"10.64898/2026.05.26.727879"},{"biol_entities":["ateds1","rubisco lsu","at5g09810","atactin7","chs3","rubisco large subunit","eds5","snc1","eds1","mapk3","mrfp","cyfp","nyfp","ics1","flg22","rfp","gfp"],"rank":3988.0,"pub_date":"2026-05-22T00:00:00Z","slug":"A-Cross-kingdom-Effector-Modulates-EDS1-dependent-TIR-NLR-mediated-Plant-Immunity","exp_assays":["bifc assays","co-immunoprecipitation assay","ponceau s","interacts","phenotypes","western blots","confocal images","immunoblots","interaction","staining","interactions","stained","localization"],"doi":"10.64898/2026.05.21.726970"},{"biol_entities":["krt19cre","ai14d","pancytokeratin","rosa26cag","pde10a","ai14","vdac2","pkac","prkaca","col4a1","krt19","dnajb1","ecori","ert","tdtomato","cre","\u03b2-actin"],"rank":3990.0,"pub_date":"2026-05-27T00:00:00Z","slug":"The-DNAJB1-PRKACA-Oncogenic-Fusion-Drives-Stepwise-Biliary-and-Pancreatic-Carcinogenesis-from-Intraductal-Precursor-Lesions","exp_assays":["trichrome stain","histology","transcriptomics","trichrome","ihc","pcr","h&e","immunohistochemical staining","confocal microscope","expression"],"doi":"10.64898/2026.05.23.727425"},{"biol_entities":["cd4ngfr","cd4lvfoxp3","cd4lvofpx3","sucrose-isomaltase","cd4act","cd4lvfox","pdgfa","chromogranin a","mucin 2","pdgf-aa","il-22","ngfr","amphiregulin","lgr5","\u03b2-catenin","chga","si","pdgfra","pdgfr\u03b1","ki67"],"rank":3992.0,"pub_date":"2026-05-28T00:00:00Z","slug":"FOXP3-engineered-regulatory-T-cells-restore-intestinal-barrier-integrity-in-Crohn-s-disease-enteroids-via-PDGF-AA","exp_assays":["single-cell sequencing","teer","confocal images","brightfield images","immunoblot","flow cytometry","stained","expression","gene expression"],"doi":"10.64898/2026.05.25.727767"},{"biol_entities":["importin \u03b22","iba1\u207a","nucleoporin","nucleoporins","importin \u03b1","iba","mag","cnp","mobp","plp1","myelin basic protein","mog","iba1","cd36","wheat germ agglutinin","wga","tlr4","cxcl10","mbp","cd11b"],"rank":4006.0,"pub_date":"2026-05-17T00:00:00Z","slug":"Myelin-basic-protein-is-an-RNA-chaperone-in-microglial-nuclear-retro-transport","exp_assays":["cblue\u2122","live-cell imaging","smfish","red","confocal","immunocytochemistry","pulldown","cell","confocal images","imaging","mass spectrometry","rt-qpcr","western blot","images","fluorescence","expression"],"doi":"10.64898/2026.05.14.725089"},{"biol_entities":["ck6","fbxl21","dnajb6","dnajb6b","dnajb6a","fus","tdp-43","desmin","ub","ubiquitin","flag","v5","chip","ha","g3bp1","hsp70"],"rank":4010.0,"pub_date":"2026-05-22T00:00:00Z","slug":"FBXL21-regulates-diurnal-proteostasis-and-stress-response-by-targeting-DNAJB6-and-client-proteins","exp_assays":["chx chase assays","ubiquitination assays","sted microscopy","fluorescence intensities","ubiquitination","co-immunoprecipitation","fluorescence intensity","immunoprecipitated","protein levels","confocal microscopy","immunofluorescence staining","interaction","imaging"],"doi":"10.64898/2026.05.20.726545"},{"biol_entities":["cdk2wt","cdk2as","hmces","\u03bb phosphatase","clover","h1","cyclin e1","cdk2","gst","flag","his","cdk1","vinculin"],"rank":4011.0,"pub_date":"2026-05-20T00:00:00Z","slug":"Direct-Mapping-of-CDK2-Substrates-in-Embryonic-Stem-Cells-Uncovers-an-AP-Site-Repair-Mechanism-via-HMCES-Phosphorylation","exp_assays":["revert stain","kinase assays","in vitro kinase assay","phos","kinase assay","emsa","sds-page","phosphorylated","phosphorylation","if","western blot"],"doi":"10.64898/2026.05.18.726044"},{"biol_entities":["ckws","adk11lm","ae1/ae3","ttf-1","nrg1","erbb2","wt1","epcam","erbb3","ncam","gapdh","egfr"],"rank":4017.0,"pub_date":"2026-05-13T00:00:00Z","slug":"Neuroendocrine-like-EMT-dedifferentiation-mediates-resistance-to-EGFR-inhibitors-via-the-NRG1-HER3-axis","exp_assays":["spheroid-forming assays","colony formation assay","-degradation assay","blotted","ihc","invasion","scrnaseq","transmission electron microscopy","tem","elisa","rt-qpcr","western blot","stained","expression"],"doi":"10.64898/2026.05.09.720556"},{"biol_entities":["atg16l","ampk\u03b11\u03b21\u03b31","ampk\u03b31","ampk\u03b11","-29","atg13","nampt","ulk1","lc3b","\u03b12","halo","ampk","cbs1","flag","mtor","gfp"],"rank":4024.0,"pub_date":"2026-05-21T00:00:00Z","slug":"AMPK-senses-cellular-levels-of-nicotinamide-adenine-dinucleotide","exp_assays":["adp-glo\u2122 assay","halo","kinase activity","assay","immunoprecipitates","ms","immunoprecipitation","lc","immunoprecipitated","luminescence","immunoblot","immunoblots","immunofluorescence","fluorescence microscopy"],"doi":"10.64898/2026.05.19.726234"},{"biol_entities":["dmra","vesicular stomatitis virus glycoprotein","dmrc","vsvg","sap","calreticulin","ldlr","dm","pcsk9","neo","tsg101","tdtomato","cre","\u03b2-actin","egfp","hsp70","gfp","cd81","cas9"],"rank":4043.0,"pub_date":"2026-05-20T00:00:00Z","slug":"An-extracellular-vesicle-biogenesis-inspired-engineering-platform-for-efficient-protein-delivery-and-therapeutic-base-editing","exp_assays":["base-editing","blots","nta","blot","immunoblot","immunoblots","flow cytometry","fluorescence microscopy"],"doi":"10.64898/2026.05.18.721905"},{"biol_entities":["p310","ubp310","kainate","gcamp8m","ef1\u237a","kar","ampars","hopx","gria2","ampar","grik3","vglut1","syn1","mirfp670","ampa","nmda","nestin","psd95","cre","egfp"],"rank":4046.0,"pub_date":"2026-05-14T00:00:00Z","slug":"Glutamatergic-neuron-tumor-synapses-shape-human-glioblastoma-cell-states-through-radial-glia-plasticity","exp_assays":["colocalizing","immunostainings","quantitative real-time pcr","stains","co-localization","immunostaining","expressing","localized","qpcr","imaging","expressed","interactions","stained","image","images","fluorescence","expression","gene expression","scrna-seq"],"doi":"10.64898/2026.05.14.725216"},{"biol_entities":["alms1wt","cep152","sas-6","alms1\u03b4ex8cells","alms1\u03b4ex8","cntrob","stil","cartwheel","cep63","plk4","centrin","alms1","nf2","\u03b3-tubulin","pcnt","p53","plk1","\u03b1-tubulin","cdk1","ha"],"rank":4052.0,"pub_date":"2026-05-20T00:00:00Z","slug":"Centriole-biogenesis-is-seeded-by-CEP152-CEP63-PCNT-aggregates-propagating-outside-the-centriole-through-the-Alstr\u00f6m-syndrome-protein-ALMS1","exp_assays":["time lapse microscopy","uexm","uexm images","exm","dstorm","ip","localized","pla","staining","western blot","localization"],"doi":"10.1101/2025.06.26.661604"},{"biol_entities":["igf2bp","sv40-t large antigen","cd43","-\u03b2","isre","tlr8","igf2bp2","tlr3","igf2bps","igf2bp3","ifn-\u03b2","rig-i","irf3","igf2bp1","ve-cadherin","nf-\u03bab","luciferase","mhc-i","gapdh","cas9"],"rank":4058.0,"pub_date":"2026-05-26T00:00:00Z","slug":"Oncofetal-RNA-binding-proteins-of-IGF2BP-family-suppress-IRF-3-and-NF-kB-dependent-transcription-downstream-of-cytosolic-RNA-sensors","exp_assays":["clip","luciferase activity","immunoprecipitation","flow cytometric","phosphorylated","qrt-pcr","rna-seq","atac-seq","western blot"],"doi":"10.64898/2026.05.22.726816"},{"biol_entities":["gsk3-\u03b2","alanine transaminase","alkaline phosphatase","eif4ebp1","rps6","prkca","ulk1","p38","\u03b2-catenin","calnexin","aspartate transaminase","albumin","4ebp1","mek","pkc\u03b1","mtor","wnt","mek1","erk","akt"],"rank":4061.0,"pub_date":"2026-05-26T00:00:00Z","slug":"Occurrence-of-Biased-mTOR-Signaling-in-Hepatocellular-Carcinoma","exp_assays":["ponceau staining","quantitative real-time pcr","body weight","weight","immunoblotting","immunoblot","qrt-pcr","survival","images"],"doi":"10.64898/2026.05.22.727188"},{"biol_entities":["apali","tp53ko","mief1","mief2","12s rrna","fastkd2","asisi","opa1","drp1","tfam","atr","53bp1","isg15","atmi","b2m","il-8","il-6","mfn2","mfn1","tomm20","actin","p21"],"rank":4063.0,"pub_date":"2026-05-25T00:00:00Z","slug":"Nuclear-DNA-Damage-Response-Triggers-Reorganization-of-Mitochondrial-Nucleic-Acids","exp_assays":["immunofluorescence images","fluorescence intensity","immunoblot","immunofluorescence","rt-qpcr","stained","expression"],"doi":"10.64898/2026.05.23.727397"},{"biol_entities":["egfrdel","gfp gr","cas12a2","ccne1","rn","grna","kap1","tp53","fluc","p53","gr","actb","myc","tdtomato","cre","egfr","gfp","p21"],"rank":4069.0,"pub_date":"2026-05-09T00:00:00Z","slug":"Selective-Elimination-of-TP53-Mutant-Cells-by-Transcript-Activated-Chromatin-Shredding","exp_assays":["growth competition assay","bioluminescence","trans","smfish","cleavage","growth curves","immunoblots","flow cytometry","growth"],"doi":"10.64898/2026.05.08.723607"},{"biol_entities":["bni5","inn1","hof1","ka1","gin4","elm1","gin4fl","gin4kd","kcc4","bud4","hsl1","shs1","gbp","hs","mng","mcherry","cdc3","gfp"],"rank":4070.0,"pub_date":"2026-05-29T00:00:00Z","slug":"Nim1-related-kinases-regulate-septin-organization-and-cytokinesis-by-modulating-Hof1-at-the-cell-division-site","exp_assays":["yeast two-hybrid","localisation","phenotype","morphology","interaction","images","intensity"],"doi":"10.1101/2025.02.07.634209"},{"biol_entities":["arginase-1","il-10","ho-1","nqo1","nrf2","iba-1","gfap","tgf-\u03b2","il-6","tnf-\u03b1","gapdh","jak2","stat3"],"rank":4071.0,"pub_date":"2026-05-27T00:00:00Z","slug":"Intranasal-Delivery-of-Hypoxia-Primed-Wharton-s-Jelly-MSC-Derived-sEVs-Reprograms-Neuroimmune-Signalling-and-Ameliorates-Behavioural-Deficits-in-a-Valproic-Acid-Induced-Mouse-Model-of-Autism-Spectrum-Disorder","exp_assays":["novel object recognition test","open field","western blots","qrt-pcr","protein expression","immunofluorescence","mrna expression","fluorescence","expression"],"doi":"10.64898/2026.05.24.721255"},{"biol_entities":["tshz1","hm3","chrmine","hm4","grm8","grab","oprm1","pdyn","mglur8","penk","dat","hm3d","hm4di","drd2","mch","da","tdt","tsh","eyfp","snrnaseq","cre","egfp","mcherry"],"rank":4073.0,"pub_date":"2026-05-28T00:00:00Z","slug":"Local-control-of-dopamine-release-in-nucleus-accumbens-gates-opioid-withdrawal-aversion","exp_assays":["voltage clamp","photometry","cpa","cpp","co-localization","activity","rnaseq","expression"],"doi":"10.64898/2026.05.25.727738"},{"biol_entities":["lamin b2","lb1","aurora a","ulk1","lamin b1","gst","plk1","\u03b1-tubulin","his","h3","actin"],"rank":4076.0,"pub_date":"2026-05-10T00:00:00Z","slug":"Mitotic-phosphorylation-of-Lamin-B1-rod-domain-by-ULK1-and-Aurora-A-PLK1-promotes-spindle-function","exp_assays":["sds_page","kinase assays","autoradiography","immunoblotted","blots","immunoblotting","densitometry","phospho","immunoblots","pla","immunofluorescence","mass spectrometry","stained"],"doi":"10.1101/2025.04.25.650690"},{"biol_entities":["aplnmu267","flt4wt","aplnwt","flt4hu4602","map2k2b","hsp70l","aplnrb","pest","fli1a","prox1a","gal4ff","gmnn","kalta4","flt4","act","dtomato","kdrl","vegfc","fli","mvenus","dsred","venus","apelin","apln","tdtomato","erk","egfp","mcherry"],"rank":4078.0,"pub_date":"2026-05-22T00:00:00Z","slug":"Vegfc-Vegfr3-Dependent-Lymphatic-Sprouting-Requires-Apelin-Signaling","exp_assays":["whole mount in situ hybridization","phenotype","cell number","confocal images","expressing","confocal image","fluorescence images","fluorescence","expression"],"doi":"10.64898/2026.04.01.715778"},{"biol_entities":["ube2n","ube2v1","pericentrin","hei10","coilin","pcm1","mbp","pml","ub","ubiquitin","flag","\u03b3h2ax","rad51"],"rank":4079.0,"pub_date":"2026-05-10T00:00:00Z","slug":"Molecular-architecture-of-meiotic-pro-crossover-factor-HEI10-reveals-coupling-of-higher-order-assembly-and-ubiquitin-chain-formation","exp_assays":["sora super-resolution imaging","ubiquitylation","sec-mals","hoechst 33342","saxs","dapi","electron micrographs","co-staining","sds-page","sec","western blot"],"doi":"10.64898/2026.05.08.723602"},{"biol_entities":["rap1bd69a","mac9","ac9y1076a","ac9wt","rap1bg12v","g\u03b1s\u207a","g\u03b1s\u207b","rap1b\u207a","rap1b\u207b","ac9","ac3","ac2","msa2","rap1b","nbalfa","rap1gap","cap1","turboid","g\u03b1s","eyfp","yfp","his","ha"],"rank":4080.0,"pub_date":"2026-05-11T00:00:00Z","slug":"Rap1b-Activates-Endosomal-AC9-to-Drive-the-Second-cAMP-Wave","exp_assays":["f\u00f6rster resonance energy transfer","proximity labeling assay","confocal micrographs","microscale thermophoresis","mst","fret","interaction","binding"],"doi":"10.64898/2026.05.06.723328"},{"biol_entities":["tax","mtco2","pink1","ifnb","ndp52","lamp2","nemo","parkin","lc3","hsp60","tom20","vinculin","mcherry","actin","gfp"],"rank":4084.0,"pub_date":"2026-05-20T00:00:00Z","slug":"HTLV-1-Tax-induces-PINK1-Parkin-dependent-mitophagy-to-mitigate-activation-of-the-cGAS-STING-pathway","exp_assays":["alexa fluor 647","co- ip","coralite\u00ae plus 488","alexa fluor 594","594","immunofluorescence confocal microscopy","potential","immunoprecipitates","dapi","co-ip","flow cytometric","tem","immunoblotting","flow cytometry","qrt-pcr","stained"],"doi":"10.1101/2025.03.15.643451"},{"biol_entities":["zbp1fl","gasdermin e","caspase-7","lysmcre","nk1.1","gasdermin d","caspase-8","casp8","zbp1","gsdme","gsdmd","ly6c","caspase-1","mlkl","casp3","ifn-\u03b3","casp7","casp1","p53","caspase-3","ly6g","siglecf","f4/80","cd45","\u03b2-actin","cd19"],"rank":4097.0,"pub_date":"2026-05-21T00:00:00Z","slug":"Defining-critical-roles-for-ZBP1-in-PANoptosis-utilizing-a-novel-genetic-tool-for-disease-modeling-and-therapeutic-development","exp_assays":["live-cell images","blots","cell death","immunoblot","densitometry","phosphorylated","flow cytometry"],"doi":"10.64898/2026.05.19.726380"},{"biol_entities":["cd45mid","cd45hi","ly6clo","ly6chi","dakar","p2ry12","nod2","ly6c","iba1","cd68","synaptophysin","homer1","cd11b","iba-1","tmem119","lamp1","cd45","cd4","cd8"],"rank":4103.0,"pub_date":"2026-05-21T00:00:00Z","slug":"NOD2-activation-reprograms-infiltrating-inflammatory-monocytes-in-the-Zika-virus-infected-CNS-to-maintain-neural-correlates-of-learning-and-memory","exp_assays":["encephalitic score","colocalized","co-localized","immunostaining","body weight","weight","qpcr","survival","stained","expression"],"doi":"10.64898/2026.05.19.726300"},{"biol_entities":["httll7","rfpt","sb2b49","ccp6","ccp5","sso7d","ccp1","ttll4","ttll5","dm1a","rfp-t","-t","335","ttll7","ttll11","a1","tgf-beta","sir","sb","eyfp","yfp","vimentin","rfp","flag","arl13b","tubulin","egfp","mcherry","gfp"],"rank":4103.0,"pub_date":"2026-05-13T00:00:00Z","slug":"Glutamylated-vimentin-proteoform-identified-by-a-synthetic-binder-links-to-epithelial-mesenchymal-plasticity","exp_assays":["cf649","gt33","glutamyl","tirfm","gt","confocal","immunostained","immunostaining","confocal images","sds-page","stained","images","facs"],"doi":"10.64898/2026.05.12.724742"},{"biol_entities":["htaur","406w","htaur406w","glaz","reaper","ptau","stat92e","hid","eiger","upd3","synapsin","htau","hop","ht","a\u03b242","au","tau","app","alpha tubulin","ampk","gfp"],"rank":4107.0,"pub_date":"2026-05-22T00:00:00Z","slug":"Microbiome-Integrity-Protects-Against-Glial-Mediated-Tau-and-Amyloid-Pathology-Through-Circadian-and-Autophagy-Homeostasis","exp_assays":["climbing distance","sleep bout","memory assay","sleep","qpcr","phospho","immunofluorescence","staining","western blot"],"doi":"10.64898/2026.05.20.726549"},{"biol_entities":["ccdc40rnai1100","ccdc40ty","ccdc40rnai1","ccdc40rnai","ccdc40","tat-1","bb2","beta-tubulin","25","ty1","mng","alpha-tubulin","tubulin","gfp"],"rank":4111.0,"pub_date":"2026-05-24T00:00:00Z","slug":"Investigating-the-axoneme-CCDC40-protein-reveals-new-insights-in-trypanosome-morphogenesis-and-division","exp_assays":["it-uexm","mab25","bb2","mab","dapi","hoechst","pcr","transmission electron microscopy","staining","western blot","stained"],"doi":"10.64898/2026.05.22.727155"},{"biol_entities":["cambp4","spicee","p2ry1","camk4","gcamp6s","eatp","idh","mrfp","gcamp6f","gq","apyrase","fibrillarin","mc","actb","mcherry","h3k27ac","calmodulin"],"rank":4114.0,"pub_date":"2026-05-14T00:00:00Z","slug":"Purinergic-signaling-promotes-gliomagenesis-through-nuclear-calcium-transients","exp_assays":["3d invasion assays","tumor sphere formation assays","transient","tumor sphere","wst-8","transients","bioluminescent images","bioluminescent imaging","bioluminescence","fluorescent images","if images","xenografted","immunohistochemistry staining","gsea","immunoblot","imaging","rna-seq","chip-seq","survival","images","expression"],"doi":"10.64898/2026.05.11.724407"},{"biol_entities":["tati","rtgmrhel","coxiii","rna3","coxi","ty1","5.8s rrna","cob","flag","ha"],"rank":4116.0,"pub_date":"2026-05-30T00:00:00Z","slug":"TgmRHel-drives-unified-RNA-processing-of-coxI-mRNA-generated-from-a-complex-mitochondrial-genomic-context","exp_assays":["5\u2032 race pcr","rna gel blot","race","3\u2019 race","plaque assays","western blots","pcr","blot","sanger sequencing","agarose gel electrophoresis","sds-page","immunofluorescence","proliferation","western blot"],"doi":"10.64898/2026.05.29.728635"},{"biol_entities":["fbxo7","fbxo7\u03b4n\u03b4prr","pi31fl","\u03b22 trypsin","fbxo7fl","pi31\u03b4prr","\u03b25 chymotrypsin","scffbxo7","fbxo7\u03b4n","fub1","\u03b2-trcp","pi31","ube2d2","caspase","cul1","skp1","\u03b2 subunits","\u03b26","\u03b25","\u03b21","\u03b22","rbx1","i\u03bab\u03b1","gst","ubiquitin","flag","trypsin","cp","ha","gfp"],"rank":4116.0,"pub_date":"2026-05-29T00:00:00Z","slug":"Regulation-of-the-proteasome-20S-core-particle-by-the-Parkinsonism-associated-Proteins-FBXO7-and-PI31","exp_assays":["peptidase activity assays","protease activity","immunoprecipitations","immunoprecipitates","immunoprecipitation","immunoblots","cryo-em"],"doi":"10.64898/2026.05.28.728263"},{"biol_entities":["apoe44","apoe23","apoe33","alox5ap","synapsin","cst3","apoe4","csf1r","il8","bhlhe40","apoe","il6","tuj1","aphid","psd95","aif1","cdkn2a","cdkn1a","p16","ccl2","p21"],"rank":4121.0,"pub_date":"2026-05-13T00:00:00Z","slug":"Impaired-lipoprotein-secretion-by-APOE4-leads-to-lysosomal-and-mitochondrial-dysfunction-in-human-microglia","exp_assays":["mmp","potential","colocalization","protein levels","scrnaseq","rnaseq","elisa","protein expression","mrna expression","staining","stained","image","expression","facs"],"doi":"10.64898/2026.05.12.724612"},{"biol_entities":["cas9","gfp","mcherry","flag","ubiquitin","mbp","tom20","hmox1","e1","bcl2","cul2","rbx1","elob","eloc","nedd8","cox15","bach1","cox10","hmox2","ube2r1","fnip1","fbxo22","alad","alas1","fbxl17","cul2fem1b","tom2062","fem1a","bach1ct","bach1l617a","bach13xflag","bach1c646s","bach1wt","fem1b"],"rank":4122.0,"pub_date":"2026-05-08T00:00:00Z","slug":"Localized-heme-sensing-through-a-ternary-molecular-glue","exp_assays":["mass spectrometry","viability","flow cytometry","cryo-em","interaction","sds-page","qpcr","pulldown","immunoprecipitated","western blotting","rna sequencing","immunoprecipitation","immunoprecipitates","coomassie staining","biolayer interferometry"],"doi":"10.64898/2026.05.07.723605"},{"biol_entities":["fam83hko","fam83hkd","dsg1","fam83h","krt","emerald","keratin","notch1","krt14","krt10","dsp","krt5","e-cadherin","gapdh"],"rank":4125.0,"pub_date":"2026-05-29T00:00:00Z","slug":"FAM83H-couples-keratin-organization-to-Notch-signaling-during-epidermal-morphogenesis","exp_assays":["fluorescence micrograph","immunoblotted","micrographs","immunostained","immunoprecipitation","western blot","stained","localization","images"],"doi":"10.64898/2026.05.26.727959"},{"biol_entities":["dync1i2","ikzf3d","sar1b","goi","sec23a","transferrin","ap2s1","tgn46","fkbp12f","dync1h1","halotag","blasticidin","v5","tubulin","bfp","cas9"],"rank":4131.0,"pub_date":"2026-05-21T00:00:00Z","slug":"A-bulk-cell-heterozygous-knock-in-strategy-for-targeted-protein-degradation","exp_assays":["ice crispr","mitosis arrest assay","live-cell imaging","assay","ib","protein level","pcr","microscope","spinning disk confocal microscope","immunoblot","stained"],"doi":"10.64898/2026.05.19.726384"},{"biol_entities":["tmp2ko","ifn-\u03b21b","tmp2","ly6e","ifitm","tmprss2","ifitm2","gfp1","gfp11","neuraminidase","hku1","ifitm1","cxcl10","\u03b2-tubulin","ace2","spike","luciferase","gapdh","gfp"],"rank":4131.0,"pub_date":"2026-05-12T00:00:00Z","slug":"Temperature-Dependent-Replication-and-Sensitivity-to-Innate-Immunity-of-Human-Coronavirus-HKU1","exp_assays":["luminex multiplex assay","high-content imaging","neutralization titers","esterase activity","cell-cell fusion","cell fusion","neutralization","fluorescence intensity","he","qpcr","flow cytometry","staining","rt-qpcr","stained","imaged","images","expression"],"doi":"10.64898/2026.05.07.723210"},{"biol_entities":["dur1","rag2\u03b4","ragmut","aresec","cdrl1","cdrl2","cdrl3","rag1","rag","hbsag","dur","rag2","tdt","hmgb1","myc","pd-l1","pd-1"],"rank":4146.0,"pub_date":"2026-05-21T00:00:00Z","slug":"A-Synthetic-Platform-for-Antibody-Junctional-Diversification-Beyond-Natural-Constraints","exp_assays":["af700","pcr","flow cytometric","sequencing","immunofluorescence staining","sds-page","elisa","binding","western blot","stained"],"doi":"10.64898/2026.05.21.726110"},{"biol_entities":["faap24","detect","prdx1i","hrdetect","brca2mut","fancm","brca1mut","parpi","recql5","cdk12","brip1","brca2","53bp1","prdx1","shld1","brca1","\u03b3h2ax","rad51","crispr"],"rank":4148.0,"pub_date":"2026-05-29T00:00:00Z","slug":"Mutational-and-functional-heterogeneity-of-homology-directed-repair-deficiency-and-clinical-implications","exp_assays":["dose response","crispr","end-seq","immunoblots","viability","immunofluorescence","survival"],"doi":"10.64898/2026.05.27.725139"},{"biol_entities":["hicam","hicam-2","hcd209","cd209","icam-2","hcd2","ezrin","icam2","il-2","ifn-\u03b3","his","fc","cd4","cd8"],"rank":4160.0,"pub_date":"2026-05-21T00:00:00Z","slug":"Myeloid-CD209-impairs-T-cell-activation-by-inducing-ICAM-2-ERM-dependent-cortical-stiffening","exp_assays":["multic","tumor","tumor growth","immunoprecipitation","immunoprecipitated","immunohistochemical staining","immunoblotting","immunoblot","flow cytometry","elisa","growth","survival"],"doi":"10.64898/2026.01.19.699861"},{"biol_entities":["rm3","mcamkii\u03b1","pinkycamp","hgfap","dlox","grab","hsyn1","hm4di","hm3dq","icre","gcamp6s","mcitrine","pvalb","vip","gcamp6f","gpcr","pacap","gi","es","sst","cre","ha","mcherry"],"rank":4161.0,"pub_date":"2026-05-21T00:00:00Z","slug":"Temporal-cortex-astrocytic-Gi-GPCR-signaling-regulates-learned-threat-responses","exp_assays":["locomotor speed","freezing","tea","epifluorescence image","epifluorescence images","behavioral tests","imaging","fluorescence","expression"],"doi":"10.64898/2026.05.21.724789"},{"biol_entities":["gyf-1",".15","simr-1","simr","pint-1","eps-1","wago","pgl","wa","gfp1","gfp11","turboid","oma-1","-1","prg-1","znfx-1","rfp","bfp","pgl-1","ha","actin","gfp"],"rank":4177.0,"pub_date":"2026-05-28T00:00:00Z","slug":"Systematic-Identification-of-Germ-Granule-Proteins-Reveals-Specialized-Roles-in-RNAi-and-Small-RNA-Inheritance","exp_assays":["fluorescence imaging","fertility assay","live imaging","localized","mrna expression","staining","localization"],"doi":"10.64898/2026.01.26.701902"}]}]